Remicade is used for the treatment of several conditions such as plaque psoriasis, rheumatoid arthritis, psoriatic arthritis, adult Crohn’s disease, ulcerative colitis and Ankylosing Spondylitis. Remicade works by blocking the action of a protein in the body called tumor necrosis factor-alpha. TNF-alpha is created by the immune system and patients with the diseases mentioned above, have too much TNF-alpha. This can cause their immune system to begin attacking healthy parts of their body. Remicade works by blocking the damage caused by an abundance of TNF-alpha.